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Literature summary extracted from
- Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II (2014), J. Lipid Res., 55, 1711-1720 .
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.17 | SKI II | noncompetitive inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II, a dual inhibitor of sphingosine kinases (SKs) 1 and 2, overview. Use of SKI II in the context of cancer therapy | Homo sapiens |  |
| 1.14.19.17 | XM462 | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.19.17 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.19.17 | gastric cancer cell | - |
Homo sapiens | - |
| 1.14.19.17 | HGC-27 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.19.17 | N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphinganine + 2 ferrocytochrome b5 + O2 + 2 H+ | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.19.17 | dihydroceramide desaturase | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.19.17 | 37 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.19.17 | 7.4 | - |
assay at | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.17 | cytochrome b5 | - |
Homo sapiens | |
| 1.14.19.17 | FAD | - |
Homo sapiens | |
| 1.14.19.17 | NADH | - |
Homo sapiens | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.19.17 | 0.0003 | - |
SKI II | pH 7.4, 37°C | Homo sapiens | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.19.17 | additional information | computational ligand docking study and simulations using enzyme structures PDB IDs BC5R and 1IB0, overview | Homo sapiens |
| 1.14.19.17 | physiological function | dihydroceramide desaturase (Des1), the last enzyme in the de novo synthesis of ceramide (Cer), regulates the balance between dihydroceramides (dhCers) and ceramides | Homo sapiens |
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